Patient-Derived
Bone Marrow Niche Models
Enabling advanced therapies for hematopoietic malignancies
by
bridging the gap between the lab and clinic
Reduce your R&D costs by 25-45%*
Evaluate drug/therapy induced hematopoietic toxicity
Test drugs/combinatory therapies for bone marrow malignancies and disorders
Develop cell and gene therapies and test their potency
Perform pre/co-clinical trials in the lab
Predict patient responses early
De-risk clinical success
Off-the-shelf
Healthy / Disease-specific
Patient / cohort-matched*
Preserves the potency of healthy and malignant cells
Enables more clinically relevant predictions of toxicity and efficacy prior to or in parallel to clinical testing.
Human & disease-relevant
Fit-for-purpose
Lab-ready
"Blood cancer evolves in the bone marrow; your drug candidate validation should too"
2. Our niche models are specifically designed to test treatment modalities for hemato-oncological disorders and compatible with:
1. Humaniche offers first-in-class human/patient bone marrow niches and micro/macro-physiological platforms combining key biochemical and biophysical features of human tissue that:
Advanced, targeted, and cell therapies and combination regimens
Repetitive tests and longitudinal analysis that also allows relapse/remission assessment
Bone Marrow Proxies
3. Our products integrate disease-specific marrow components within physiologically relevant, lab-compatible, and plug-&-play architectures that each is available in 3 product configurations:
*Currently available, ready to test marrow niche models of:
- Acute myeloid leukemia (AML)
- Myelodysplastic syndromes (MDS)
*Soon available, ready to test marrow niche models of:
- Multiple Myeloma (MM)
- Myelofibrosis (PMF)
of blood cancer drug candidates fail during clinical development.
90 %
75 %
of failures are linked to lack of efficacy or unexpected toxicity.
Current preclinical models often fail to accurately predict patient response to treatment.
Why act now?
Discover the Humaniche Approach
Our Team
Meet the minds behind advancing translational research through next-generation 3D bone marrow niche models.
Our Models
Explore the technologies behind our human-relevant bone marrow platforms, from biomimetic niche development to advanced 3D tissue engineering.
Partnernships
Work with us to accelerate discovery and therapeutic development using physiologically relevant 3D bone marrow niche models.
Ready to run your compounds against a characterized niche model?
Contact our team to discuss your program, request lot-characterization documentation, or begin an order. We respond within 1-2 business days.
