Human-Relevant. Reproducible. Predictive.

We offer:

Physiologically representative bone marrow niche systems designed to improve translational relevance between preclinical blood cancer research and clinical outcomes
Multicellular microenvironments incorporating intersititial networks to study hematopoiesis, leukemia progression, and therapeutic response with enhanced biological fidelity
Biomimetic extracellular matrices engineered to support stem cell maintenance, tumor–niche interactions, immune crosstalk, and disease progression in 3D culture systems
Integrated stromal and vascular networks supporting realistic nutrient transport, cellular signaling, and therapeutic exposure throughout the tissue construct
Perfused culture environments which enable more physiologically relevant studies of drug response, immune interactions, and cell migration dynamics
Complex multicellular niche architectures that support long-term culture, repeated-dose experiments, and extended evaluation of disease progression and therapeutic efficacy

Overhead close-up of an acute myeloid leukemia bone marrow tissue section on a glass slide under cool controlled lab lighting, revealing dense blast cell clusters within stromal matrix, muted monochrome palette

Overhead close-up of a myelodysplastic syndrome bone marrow biopsy cross-section under controlled studio lighting, showing dysplastic cell morphology within fibrous stroma, desaturated ivory and slate tones

Close-up overhead of a multiple myeloma bone marrow core biopsy on a preparation surface under neutral studio lighting, plasma cell infiltration visible within trabecular architecture, high-contrast monochrome

Overhead macro photograph of an aplastic anemia bone marrow biopsy section under controlled cool lighting, hypocellular marrow space visible with sparse stromal elements, muted gray and bone-white tones

Select your disease indication

Hematologic Malignancy

Plasma Cell Dyscrasia

Bone Marrow Failure

AML Niche Model

MDS Niche Model

Myeloma Niche Model

Aplastic Anemia Model

Stromal architecture recapitulating acute myeloid leukemia. Validated for cytarabine and venetoclax compound screening with lot-to-lot disease-profile characterization.

Recapitulates the dysplastic marrow niche for myelodysplastic syndrome. Suitable for hypomethylating agent screening and clonal evolution studies.

Engineered plasma cell niche for multiple myeloma. Validated for proteasome inhibitor and IMiD compound screening with published stromal characterization per lot.

Hypocellular marrow niche for aplastic anemia toxicology and hematopoietic recovery studies. Lot characterization includes cellularity index and stromal viability metrics.

Know exactly what you need before you order

Input your assay format, replicates, and compound count. The calculator returns the minimum lot quantity required and flags lot-characterization constraints relevant to your study design.

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Ready to run compounds against validated marrow biology?

Contact our team to confirm model availability, discuss lot-to-lot characterization requirements, or initiate a partnership order for your program.